Remogliflozin

Base Information

Chemical Name:Remogliflozin
CAS No.:329045-45-6
Molecular Formula:C₂₃H₃₄N₂O₇
Molecular Weight:450.532
Hs Code.:
UNII:13ZPK7A4MJ
DSSTox Substance ID:DTXSID30186563
Wikidata:Q83057891
Pharos Ligand ID:X8RVVMM93RM9
ChEMBL ID:CHEMBL3958686
Mol file:329045-45-6.mol

Synonyms:remogliflozin;Remogliflozin A;329045-45-6;UNII-13ZPK7A4MJ;13ZPK7A4MJ;GSK 189074;beta-D-Glucopyranoside, 5-methyl-4-((4-(1-methylethoxy)phenyl)methyl)-1-(1-methylethyl)-1H-pyrazol-3-yl;(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxane-3,4,5-triol;REMOGLIFLOZIN [WHO-DD];SCHEMBL2253397;CHEMBL3958686;DTXSID30186563;GSINGUMRKGRYJP-VZWAGXQNSA-N;BDBM50559517;GSK189074;GSK-189074;BR162757;HY-13414;CS-0006772;E98919;3-(beta-D-glucopyranosyloxy)-4-[(4-iso-propoxyphenyl)methyl]-1-isopropyl-5-methylpyrazole;3-(beta-D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-1-isopropyl-5-methylpyrazole;(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yloxy)tetrahydro-2H-pyran-3,4,5-triol;.BETA.-D-GLUCOPYRANOSIDE, 5-METHYL-4-((4-(1-METHYLETHOXY)PHENYL)METHYL)-1-(1-METHYLETHYL)-1H-PYRAZOL-3-YL;|A-?D-?Glucopyranoside, 5-?methyl-?4-?[[4-?(1-?methylethoxy)?phenyl]?methyl]?-?1-?(1-?methylethyl)?-?

Suppliers and Price of Remogliflozin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Remogliflozin A ≥98%
1mg
$ 70.00

Cayman Chemical
Remogliflozin A ≥98%
500μg
$ 37.00

Cayman Chemical
Remogliflozin A ≥98%
5mg
$ 333.00

Cayman Chemical
Remogliflozin A ≥98%
10mg
$ 592.00

AK Scientific
RemogliflozinA
5mg
$ 549.00

AK Scientific
RemogliflozinA
1mg
$ 194.00

Total 14 raw suppliers

Chemical Property of Remogliflozin

Chemical Property:

Boiling Point:637.6±55.0 °C(Predicted)
PKA:12.66±0.70(Predicted)
Density:1.33±0.1 g/cm3(Predicted)
XLogP3:2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:450.23660143
Heavy Atom Count:32
Complexity:573

Purity/Quality:

99% ^*data from raw suppliers

Remogliflozin A ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=NN1C(C)C)OC2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(C=C3)OC(C)C
Isomeric SMILES:CC1=C(C(=NN1C(C)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(C=C3)OC(C)C

Technology Process of Remogliflozin

There total 18 articles about Remogliflozin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4-[(4-isopropoxyphenyl)methyl]-1-isopropyl-5-methyl-3-(2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyloxy)-1H-pyrazole

: 329045-45-6
[14C]-Remogliflozin

Guidance literature:: With methanol; sodium methylate; at 20 - 55 ℃; for 3h;
DOI:10.1248/cpb.c15-00982

Reference yield:

: 1338796-70-5
5-methyl-1-(propan-2-yl)-4- [4-(propan-2-yloxy)benzyl]-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

: 329045-45-6
[14C]-Remogliflozin

Guidance literature:: With water; sodium hydroxide; In tert-butyl alcohol; at 38 ℃; for 1h; Inert atmosphere;

Reference yield:

: 572-09-8,3068-32-4,4026-32-8,6919-96-6,13242-53-0,14227-54-4,14795-18-7,19186-59-5,19285-38-2,21698-13-5,29907-26-4,53369-42-9,60619-58-1,61303-35-3,67337-79-5,69127-37-3,70749-15-4,72002-90-5,75247-30-2,75880-74-9,78418-57-2,102339-89-9,102339-90-2,103530-40-1,114028-03-4,114718-45-5,138514-70-2,138514-71-3
2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide

: 1028026-83-6
5-methyl-1-(propan-2-yl)-4-[4-(propan-2-yloxy)benzyl]-1,2-dihydro-3H-pyrazol-3-one

: 329045-45-6
[14C]-Remogliflozin

Guidance literature:: 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl bromide; 5-methyl-1-(propan-2-yl)-4-[4-(propan-2-yloxy)benzyl]-1,2-dihydro-3H-pyrazol-3-one; With lithium hydroxide monohydrate; In tert-butyl alcohol; at 40 ℃; for 5h;

With sodium hydroxide; In tert-butyl alcohol; for 2h;