Technology Process of 3-(4-ethynyl)phenyl-6-methyl-1,2,4,5-tetrazine
There total 4 articles about 3-(4-ethynyl)phenyl-6-methyl-1,2,4,5-tetrazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; silver nitrate;
In
acetone;
at 20 ℃;
for 24h;
Darkness;
DOI:10.1039/c4ob00245h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; sodium nitrite / water / 0.5 h / Inert atmosphere
2: silver nitrate; water / acetone / 24 h / 20 °C / Darkness
With
water; silver nitrate; acetic acid; sodium nitrite;
In
water; acetone;
DOI:10.1039/c4ob00245h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrazine hydrate; nickel(II) triflate / 24 h / 60 °C / Sealed tube
1.2: pH 3 / Sealed tube
2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: acetic acid; sodium nitrite / water / 0.5 h / Inert atmosphere
4.1: silver nitrate; water / acetone / 24 h / 20 °C / Darkness
With
nickel(II) triflate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; hydrazine hydrate; silver nitrate; acetic acid; triethylamine; sodium nitrite;
In
water; N,N-dimethyl-formamide; acetone;
2.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00245h
