tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate
CAS No.:1402047-72-6
Molecular Formula:C₂₁H₂₉F₃N₂O₃
Molecular Weight:414.468
Hs Code.:

Synonyms:tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1402047-76-0
tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

: 2633-66-1
2-mesitylmagnesium bromide

: 1402047-72-6
tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate; 2-mesitylmagnesium bromide; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In diethyl ether;
DOI:10.1002/anie.201204481

Reference yield:

: 1402047-78-2
C₁₇H₂₄N₂O₂

: 1402047-72-6
tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogen fluoride; trifluoroacetic acid / acetonitrile; N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2.1: formic acid; 10% Pd/C; hydrogen / methanol / 12 h / 45 °C

2.2: Inert atmosphere

3.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

4.1: diethyl ether / -78 - 20 °C / Inert atmosphere

With formic acid; potassium hydrogen fluoride; 10% Pd/C; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201204481

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1402047-72-6
tert-butyl 4-(trifluoromethyl)-4-(2,4,6-trimethylbenzamido)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzene / 5 h / Reflux; Inert atmosphere

2.1: potassium hydrogen fluoride; trifluoroacetic acid / acetonitrile; N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: formic acid; 10% Pd/C; hydrogen / methanol / 12 h / 45 °C

3.2: Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

5.1: diethyl ether / -78 - 20 °C / Inert atmosphere

With formic acid; potassium hydrogen fluoride; 10% Pd/C; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/anie.201204481