(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Name:(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid
CAS No.:1418712-65-8
Molecular Formula:C₂₈H₂₉FN₂O₃
Molecular Weight:460.548
Hs Code.:

Synonyms:(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Property of (S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Technology Process of (S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

There total 13 articles about (S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392119-96-8
2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

: 1418712-65-8
(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: With formic acid; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1418717-44-8
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 1418712-65-8
(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

3: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

4: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

5: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

6: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

7: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

8: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

9: sulfuric acid / 18 h / 760.05 Torr / Cooling with ice; Reflux

10: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

11: lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C / 760.05 Torr

12: formic acid / isopropyl alcohol; hexane / Resolution of racemate

With lithium aluminium tetrahydride; formic acid; perchloric acid; sulfuric acid; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1418717-47-1
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

: 1418712-65-8
(S)-2-(tert-butoxy)-2-(1-(4-fluorobenzyl)-6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1 h / 0 °C / 760.05 Torr

2: pyridinium chlorochromate / dichloromethane / 24 h / 20 °C / 760.05 Torr

3: caesium carbonate / methanol; hexane / 1 h / 60 °C / 760.05 Torr

4: caesium carbonate / acetonitrile / 1.5 h / 70 °C / 760.05 Torr

5: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / 760.05 Torr / Cooling with ice

6: pyridinium chlorochromate / dichloromethane / 18 h / 20 °C / 760.05 Torr

7: zinc(II) iodide / dichloromethane / 1 h / 20 °C / 760.05 Torr / Cooling with ice

8: sulfuric acid / 18 h / 760.05 Torr / Cooling with ice; Reflux

9: perchloric acid / 0.67 h / 20 °C / 760.05 Torr

10: lithium hydroxide / tetrahydrofuran; methanol / 18 h / 60 °C / 760.05 Torr

11: formic acid / isopropyl alcohol; hexane / Resolution of racemate

With lithium aluminium tetrahydride; formic acid; perchloric acid; sulfuric acid; caesium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; zinc(II) iodide; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; toluene; acetonitrile;