benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

Base Information

Chemical Name:benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate
CAS No.:1200572-67-3
Molecular Formula:C₂HF₃O₂*C₃₃H₃₉N₃O₇S
Molecular Weight:735.779
Hs Code.:

Synonyms:benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

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Chemical Property of benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

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Technology Process of benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

There total 3 articles about benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 433688-20-1
4-iodo-N-(2-morpholin-4-yl-ethyl)benzene-sulfonamide

: 1200575-51-4
benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 201733-56-4
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: 1200572-67-3
benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

Guidance literature:: benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 90 ℃; for 1h;

4-iodo-N-(2-morpholin-4-yl-ethyl)benzene-sulfonamide; With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1200572-67-3
benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

2.2: 90 °C

With potassium acetate; toluene-4-sulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; chloroform;

Reference yield:

: 2316-64-5
5-bromo-2-hydroxybenzyl alcohol

: 1200572-67-3
benzyl 4-[6-(4-{[(2-morpholin-4-ylethyl)amino]sulfonyl}phenyl)-4H-1,3-benzodioxin-2-yl]piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

2.2: 90 °C

With potassium acetate; toluene-4-sulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; chloroform;