tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

Base Information

Chemical Name:tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate
CAS No.:1266105-27-4
Molecular Formula:C₂₇H₃₄O₆
Molecular Weight:454.563
Hs Code.:

Synonyms:tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

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Chemical Property of tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

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Technology Process of tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

There total 2 articles about tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1266105-26-3
tert-butyl 6-((Z)-2-(methoxycarbonyl)-2-iodovinyloxy)hexanoate

: 190661-29-1
2-benzyloxyphenylboronic acid

: 1266105-27-4
tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.054

Reference yield:

: 73839-20-0
tert-butyl 6-hydroxyhexanoate

: 1266105-27-4
tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tributylphosphine / dichloromethane / 0.58 h / 0 - 20 °C / Inert atmosphere

2.1: N-iodo-succinimide; acetic acid / dichloromethane / 17 h / 20 °C / Inert atmosphere

2.2: 22 h / 20 °C / Inert atmosphere

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 7 h / 90 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tributylphosphine; acetic acid; In 1,4-dioxane; dichloromethane; water; 3.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2010.11.054

Reference yield: 84.0%

: 1266105-27-4
tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-(benzyloxy)phenyl)vinyloxy)hexanoate

: 1266105-28-5
tert-butyl 6-((E)-2-(methoxycarbonyl)-2-(2-hydroxyphenyl)vinyloxy)hexanoate

Guidance literature:: With 10% palladium on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1h; under 760.051 Torr;
DOI:10.1016/j.tet.2010.11.054