N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Base Information

Chemical Name:N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide
CAS No.:138483-81-5
Molecular Formula:C₃₉H₅₁N₃O₆S
Molecular Weight:689.916
Hs Code.:

Synonyms:N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Suppliers and Price of N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

There total 12 articles about N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 63906-73-0
2-(4-thiomorpholinyl)-ethyl chloride

: 138498-62-1
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-[1,1-dimethylethoxy-carbonylamino]-4(S)-hydroxy-6-phenyl-2(R)-(4-hydroxyphenylmethyl) hexanamide

: 138483-81-5
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Guidance literature:: With caesium carbonate; In 1,4-dioxane; at 80 ℃; for 1h;
DOI:10.1021/jm00088a003

Reference yield:

: N-((1S,2S)-2-Hydroxy-indan-1-yl)-benzamide

: 138483-81-5
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Guidance literature:: Multi-step reaction with 9 steps

1: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

2: 88 percent / aq. H₂SO₄ / H₂O / 16 h / Heating

3: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h

4: 40 percent / trifluoroacetic acid / CHCl₃ / 2.5 h

5: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating

6: 66 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

7: 8.5 g / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

8: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 96 h

9: 75 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a003

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
trans-1-aminoindan-2-ol

: 138483-81-5
N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(thiamorpholin-4-yl)ethoxy>phenyl>methyl>hexanamide

Guidance literature:: Multi-step reaction with 10 steps

1: 20percent aq. NaOH / toluene / 24 h

2: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / aq. H₂SO₄ / H₂O / 16 h / Heating

4: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h

5: 40 percent / trifluoroacetic acid / CHCl₃ / 2.5 h

6: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating

7: 66 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h

8: 8.5 g / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h

9: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 96 h

10: 75 percent / Cs₂CO₃ / dioxane / 1 h / 80 °C

With 4-methyl-morpholine; sodium hydroxide; thionyl chloride; dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00088a003