4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Base Information

Chemical Name:4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile
CAS No.:249621-37-2
Molecular Formula:C₂₁H₄₁NO₃Si
Molecular Weight:383.647
Hs Code.:

Synonyms:4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Suppliers and Price of 4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

There total 2 articles about 4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 3483-39-4
Cyclohexyloxirane

: 3634-56-8
isopropyldimethylsilyl chloride

: 18381-45-8
4,4-diethoxybutanenitrile

: 249621-37-2
4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Guidance literature:: 4,4-diethoxybutanenitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Cyclohexyloxirane; In tetrahydrofuran; hexane; at -78 - 20 ℃;

isopropyldimethylsilyl chloride; In tetrahydrofuran; hexane; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(99)00613-4

Reference yield:

: 695-12-5,25498-06-0
vinylcyclohexane

: 249621-37-2
4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 66 percent / mCPBA

2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

2.3: 85 percent / tetrahydrofuran; hexane / 0 - 20 °C

With n-butyllithium; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; 1.1: Oxidation / 2.1: Metallation / 2.2: Addition / 2.3: Substitution;
DOI:10.1016/S0040-4020(99)00613-4

Reference yield: 93.0%

: 249621-37-2
4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile

: 249621-38-3
4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanal

Guidance literature:: 4-cyclohexyl-2-(2,2-diethoxyethyl)-4-[[(dimethyl)isopropylsilyl]oxy]-butanenitrile; With diisobutylaluminium hydride; In diethyl ether; decane; toluene; at -50 - -40 ℃; for 1h;

With sodium sulfate; In diethyl ether; decane; toluene; at 20 ℃; for 1h;

With silica gel; In ethyl acetate; at 20 ℃;
DOI:10.1016/S0040-4020(99)00613-4