1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

Base Information

Chemical Name:1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone
CAS No.:172937-03-0
Molecular Formula:C₃₁H₂₇NO₄
Molecular Weight:477.56
Hs Code.:

Synonyms:1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

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Chemical Property of 1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

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Technology Process of 1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

There total 7 articles about 1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 172936-70-8
1-[(3,4-Dihydro-5-ethoxycarbonylmethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

: 172937-03-0
1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

Guidance literature:: With sodium hydroxide; In 1,2-dimethoxyethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00571-0

Reference yield:

: 116503-68-5
methyl 5-methoxy-3,4-dihydro-2-naphthoate

: 172937-03-0
1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / DIBAL-H / toluene / 5 °C

2: 100 percent / CBr₄; PPh₃ / CH₂Cl₂ / 20 °C

3: tBuOK; 18-crown-6; 5-benzhydryl-2-pyridone / dimethylformamide / 20 °C

4: 66 percent / BBr₃ / CH₂Cl₂ / 0 °C

5: 72 percent / K₂CO₃ / acetonitrile / Heating

6: 71 percent / 1N aq. NaOH / 1,2-dimethoxy-ethane / 20 °C

With sodium hydroxide; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; boron tribromide; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; 5-(diphenylmethyl)-2(1H)-pyridone; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0960-894X(00)00571-0

Reference yield:

: 172937-42-7
3-bromomethyl-1,2-dihydro-8-methoxynaphthalene

: 172937-03-0
1-[(3,4-Dihydro-5-carboxymethoxy-2-naphthyl)methyl]-3-diphenylmethyl-2(1H)-pyridone

Guidance literature:: Multi-step reaction with 4 steps

1: tBuOK; 18-crown-6; 5-benzhydryl-2-pyridone / dimethylformamide / 20 °C

2: 66 percent / BBr₃ / CH₂Cl₂ / 0 °C

3: 72 percent / K₂CO₃ / acetonitrile / Heating

4: 71 percent / 1N aq. NaOH / 1,2-dimethoxy-ethane / 20 °C

With sodium hydroxide; 18-crown-6 ether; potassium tert-butylate; boron tribromide; potassium carbonate; 5-(diphenylmethyl)-2(1H)-pyridone; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(00)00571-0