(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

Base Information

Chemical Name:(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol
CAS No.:632354-64-4
Molecular Formula:C₃₀H₄₀O₇
Molecular Weight:512.643
Hs Code.:

(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

Synonyms:(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

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Chemical Property of (2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

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Technology Process of (2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

There total 10 articles about (2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 632354-56-4
(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-benzyloxy-8-benzyloxymethyl-2-(tert-butyldiphenylsilyloxymethyl)-2,11a-dimethyldodecahydro-1,5,9-trioxadibenzo[a,d]cyclohepten-3-ol

: 632354-64-4
(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.16667h;
DOI:10.1021/jo035145d

Reference yield:

: 632354-52-0
(2R,3S,4aR,6S,7R,9aS)-3-benzyloxy-2-benzyloxymethyl-6-hydroxymethyl-7-methyloctahydro-1,5-dioxabenzocyclohepten-7-ol

: 632354-64-4
(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

2: 1.32 g / 2,6-lutidine / CH₂Cl₂ / 0.75 h

3: 90 percent / n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.5 h / -100 °C

4: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / 20 °C

5: 98 percent / NaBH₄ / CH₂Cl₂; methanol / 0.5 h / 0 °C

6: 100 percent / TBAF / tetrahydrofuran / 1.17 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo035145d

Reference yield:

: Trifluoro-methanesulfonic acid (2R,3S,4aR,6S,7R,9aS)-3-benzyloxy-2-benzyloxymethyl-7-hydroxy-7-methyl-octahydro-1,5-dioxa-benzocyclohepten-6-ylmethyl ester

: 632354-64-4
(2S,3R,4aS,5aR,7S,8R,9aS,11aR)-7-Benzyloxy-8-benzyloxymethyl-2-hydroxymethyl-2,11a-dimethyl-dodecahydro-1,5,9-trioxa-dibenzo[a,d]cyclohepten-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.32 g / 2,6-lutidine / CH₂Cl₂ / 0.75 h

2: 90 percent / n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.5 h / -100 °C

3: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / 20 °C

4: 98 percent / NaBH₄ / CH₂Cl₂; methanol / 0.5 h / 0 °C

5: 100 percent / TBAF / tetrahydrofuran / 1.17 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1021/jo035145d