2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Base Information

Chemical Name:2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine
CAS No.:359785-62-9
Molecular Formula:C₃₅H₅₀N₄O₄Si₂
Molecular Weight:646.977
Hs Code.:

2-phenyl-O<sup>6</sup>-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Synonyms:2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Suppliers and Price of 2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

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Technology Process of 2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

There total 5 articles about 2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 865710-39-0
O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 98-80-6
phenylboronic acid

: 359785-62-9
2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Guidance literature:: With palladium diacetate; potassium phosphate; CyJohnPhos; In 1,4-dioxane; at 90 ℃; for 3h;
DOI:10.1021/jo050847j

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 359785-62-9
2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃; DEAD / dioxane

2: 20 percent / tert-butylnitrite; chlorotrimethylsilane / CH₂Cl₂ / -10 °C

3: 62 percent / Pd(OAc₀₂; 2-(dicyclohexylphosphino)biphenyl; K₃PO₄ / dioxane / 3 h / 90 °C

With palladium diacetate; potassium phosphate; chloro-trimethyl-silane; tert.-butylnitrite; triphenylphosphine; CyJohnPhos; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jo050847j

Reference yield:

: 961-07-9
2'-Deoxyguanosine

: 359785-62-9
2-phenyl-O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: PPh₃; DEAD / dioxane

3: 20 percent / tert-butylnitrite; chlorotrimethylsilane / CH₂Cl₂ / -10 °C

4: 62 percent / Pd(OAc₀₂; 2-(dicyclohexylphosphino)biphenyl; K₃PO₄ / dioxane / 3 h / 90 °C

With 1H-imidazole; palladium diacetate; potassium phosphate; chloro-trimethyl-silane; tert.-butylnitrite; triphenylphosphine; CyJohnPhos; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo050847j