(1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Base Information

• Chemical Name: (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
• CAS No.: 84681-43-6
• Molecular Formula: C₁₃H₂₀ClN₂O₂P
• Molecular Weight: 302.741
• Mol file: 84681-43-6.mol

Synonyms:(1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Chemical Property of (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide

There total 2 articles about (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(1-Ethylenimino)-1-propanol (31190-87-1) → (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide (84681-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / triethylamine, phosphoryl chloride / benzene / 4 h

2: triethylamine / benzene / 15 h

With triethylamine; trichlorophosphate; In benzene;

DOI:10.1021/jm00359a010

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) + 3-(chloroethyl)-2-chlorooxaazaphosphorinane 2-oxide (81485-04-3) → (1'R,2R)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide (84681-44-7) + (1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide (84681-43-6)

Guidance literature:

With triethylamine; In benzene; for 15h;

DOI:10.1021/jm00359a010

Reference yield: 47.0%

(1'R,2S)-2-<(1'-methylbenzyl)amino>-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide (84681-43-6) → (+)-2-Dechloroethylifosfamide (83802-21-5,105308-45-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 96h; Ambient temperature;

DOI:10.1021/jm00359a010

upstream raw materials:

(R)-1-phenyl-ethyl-amine

3-(chloroethyl)-2-chlorooxaazaphosphorinane 2-oxide

3-(1-Ethylenimino)-1-propanol

Downstream raw materials:

(+)-2-Dechloroethylifosfamide

ilfosfamide