2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

Base Information

Chemical Name:2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine
CAS No.:1072269-75-0
Molecular Formula:C₂₄H₂₅N₅O₃S
Molecular Weight:463.56
Hs Code.:

Synonyms:2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

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Chemical Property of 2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

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Technology Process of 2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

There total 4 articles about 2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1072269-73-8
{2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester

: 1072269-75-0
2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

Guidance literature:: {2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 1072269-65-8
2-(4-chloro-6-morpholin-4-yl-pyrimidin-2-yl)-ethylamine

: 1072269-75-0
2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / acetonitrile / 17 h / 20 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 - 0.5 h / 125 °C / Microwave irradiation

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dmap; sodium hydride; caesium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; 2.1: Suzuki Coupling;

Reference yield:

: 1072269-67-0
[2-(4-chloro-6-morpholin-4-yl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester

: 1072269-75-0
2-[4-(1-benzenesulfonyl-1H-indol-4-yl)-6-morpholin-4-yl-pyrimidin-2-yl]-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 - 0.5 h / 125 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

2.2: 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydride; caesium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: Suzuki Coupling;