(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

Base Information

Chemical Name:(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde
CAS No.:960294-53-5
Molecular Formula:C₃₆H₅₀O₅Si₂
Molecular Weight:618.961
Hs Code.:

Synonyms:(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

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Chemical Property of (-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

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Technology Process of (-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

There total 2 articles about (-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 960294-52-4
tert-butyl(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-vinylcyclobutyl)methoxy)diphenylsilane

: 960294-53-5
(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

Guidance literature:: tert-butyl(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-1-vinylcyclobutyl)methoxy)diphenylsilane; With oil scarlet; ozone; In dichloromethane; at -78 ℃;

With triphenylphosphine; In dichloromethane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo8004233

Reference yield:

: C₃₇H₅₄O₇Si₂

: 960294-53-5
(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

Guidance literature:: With triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/anie.200702056

Reference yield: 96.0%

: 960294-53-5
(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde

: 95106-80-2
2,2-dimethylpent-4-enyl iodide

: 960294-54-6
C₄₃H₆₄O₅Si₂

Guidance literature:: 2,2-dimethylpent-4-enyl iodide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

(-)-(1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutanecarbaldehyde; In tetrahydrofuran; at -78 ℃; for 1h; Further stages.;
DOI:10.1002/anie.200702056