6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

Base Information

Chemical Name:6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one
CAS No.:864933-23-3
Molecular Formula:C₂₉H₂₉NO₆
Molecular Weight:487.552
Hs Code.:

6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-<i>b</i>]isoquinolin-3-one

Synonyms:6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

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Chemical Property of 6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

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Technology Process of 6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

There total 4 articles about 6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 864933-22-2
8-benzyloxy-1-benzyloxymethyl-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-1H-isoquinoline-2-carboxylic acid methyl ester

: 864933-23-3
6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -10 - 25 ℃;
DOI:10.1021/ja0535817

Reference yield: 86.0%

: 1384282-93-2
C₃₀H₃₃NO₇

: 864933-23-3
6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

Guidance literature:: With sodium methylate; In methanol; at 25 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.tet.2012.02.043

Reference yield:

: 864933-21-1
8-benzyloxy-5,7-dimethoxy-6-methyl-3-triisopropylsilanyloxymethyl-isoquinoline

: 864933-23-3
6-benzyloxy-5-benzyloxymethyl-7,9-dimethoxy-8-methyl-1,5-dihydro-oxazolo[3,4-b]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.92 h / -10 - 25 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2012.02.043