methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate
• CAS No.: 1010128-92-3
• Molecular Formula: C₂₃H₂₄NO₃P
• Molecular Weight: 393.422
• Mol file: 1010128-92-3.mol

Synonyms:methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate

Chemical Property of methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate

There total 1 articles about methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

P-diphenyl(N-benzyl-N-methyl)-λ5-phosphinamide (62369-76-0) + bromoacetic acid methyl ester (96-32-2) → methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate (1010128-92-3)

Guidance literature:

P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide; With tert.-butyl lithium; In diethyl ether; hexane; at -90 ℃; for 2h;

bromoacetic acid methyl ester; In diethyl ether; hexane; at -90 ℃; for 0.5h; Further stages.;

DOI:10.1021/ol7028096

Reference yield: 96.0%

methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate (1010128-92-3) → 4-(methylamino)-4-(phenyl)butanoic acid

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 0.5h;

DOI:10.1021/ol7028096

Reference yield: 92.0%

methyl 3-[(diphenylphosphoryl)(methyl)amino]-3-phenylpropanoate (1010128-92-3) → (R,S)-N-methyl-β-phenyl-β-alanine (76497-43-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 0.5h;

DOI:10.1021/ol7028096

upstream raw materials:

P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide

bromoacetic acid methyl ester

Downstream raw materials:

(R,S)-N-methyl-β-phenyl-β-alanine