(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

Base Information

Chemical Name:(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol
CAS No.:109961-15-1
Molecular Formula:C₁₈H₂₇NO₃
Molecular Weight:305.417
Hs Code.:

Synonyms:(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

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Chemical Property of (4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

Chemical Property:

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Technology Process of (4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

There total 6 articles about (4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96648-92-9
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-hydroxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

: 109961-15-1
(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

2: 90 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 93086.7 Torr

3: alane / Ambient temperature

4: acid / hydrolysis

With calcium sulfate; hydrogen; aluminium hydride; silver(l) oxide; palladium dihydroxide; In methanol;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-91-8
(4aR^*,5S^*,6S^*,7R^*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone

: 109961-15-1
(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

2: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

3: 90 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 93086.7 Torr

4: alane / Ambient temperature

5: acid / hydrolysis

With calcium sulfate; hydrogen; aluminium hydride; lithium 2-ethylhexanoate; silver(l) oxide; palladium dihydroxide; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-90-7,109961-10-6
(4aR^*,5S^*)-2-benzyl-5-((methoxymethoxy)methyl)-3,4,4a,5-tetrahydro-1(2H)-isoquinolone

: 109961-15-1
(4aR,5S,6S,7S,8aR)-2-Benzyl-5-hydroxymethyl-6-methoxy-decahydro-isoquinolin-7-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 14 h / 0 °C

2: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

3: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

4: 90 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h / 93086.7 Torr

5: alane / Ambient temperature

6: acid / hydrolysis

With calcium sulfate; hydrogen; aluminium hydride; lithium 2-ethylhexanoate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; palladium dihydroxide; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja00254a036