(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1394169-64-2
Molecular Formula:C₂₄H₂₁ClN₂O₃
Molecular Weight:420.895
Hs Code.:

Synonyms:(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

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Technology Process of (S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 1 articles about (S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-47-8
4-chloro-aniline

: 79261-58-8
(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester

: 1394169-64-2
(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield: 100.0%

: 1394169-64-2
(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: (S)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: With 10% Pd(OH)₂ on C; hydrogen; In methanol; tert-butyl alcohol; at 20 ℃;
DOI:10.1016/j.ejmech.2012.06.032

Reference yield:

: 1394169-64-2
(S)-benzyl 3-(4-chlorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1394169-65-3
(S)-N-(4-chlorophenyl)-2-(4-(2-oxopiperidin-1-yl)benzoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 10% Pd(OH)₂ on C; hydrogen / methanol; tert-butyl alcohol / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; 10% Pd(OH)₂ on C; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.06.032