5-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 5-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid
• CAS No.: 1038398-68-3
• Molecular Formula: C₁₁H₇F₃N₂O₂
• Molecular Weight: 256.184
• Hs Code.: 2933199090
• Mol file: 1038398-68-3.mol

Synonyms:5-(4-trifluoromethyl-phenyl)-1H-pyrazole-3-carboxylic acid

Chemical Property of 5-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-(4-(Trifluoromethyl)phenyl)-1H-pyrazole-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 5-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid

There total 3 articles about 5-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H9F3N2O2 → 3-(4-trifluoromethylphenyl)-1H-pyrazole-5-carboxylic acid (1038398-68-3)

Guidance literature:

With sodium hydroxide; In methanol; water; at 50 ℃;

DOI:10.3390/ph14040371

Reference yield:

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → 3-(4-trifluoromethylphenyl)-1H-pyrazole-5-carboxylic acid (1038398-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / toluene; tetrahydrofuran / 20 °C

2: hydrazine hydrate; acetic acid / 4 h / 90 °C

3: sodium hydroxide / methanol; water / 50 °C

With hydrazine hydrate; potassium tert-butylate; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene; 1: |Claisen Condensation;

DOI:10.3390/ph14040371

Reference yield:

methyl 2,4-dioxo-4-(4-(trifluoromethyl)phenyl)butanoate (608537-00-4) → 3-(4-trifluoromethylphenyl)-1H-pyrazole-5-carboxylic acid (1038398-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; acetic acid / 4 h / 90 °C

2: sodium hydroxide / methanol; water / 50 °C

With hydrazine hydrate; acetic acid; sodium hydroxide; In methanol; water;

DOI:10.3390/ph14040371

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

methyl 2,4-dioxo-4-(4-(trifluoromethyl)phenyl)butanoate

Downstream raw materials:

5-(4-trifluoromethylphenyl)-1H-pyrazole-3-carboxylic acid {2-[4-(2-chlorophenoxy)piperidin-1-yl]-2-oxoethyl}amide

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