N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

Base Information

Chemical Name:N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide
CAS No.:123076-73-3
Molecular Formula:C₂₀H₃₀N₂O₃Si
Molecular Weight:374.555
Hs Code.:

Synonyms:N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

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Chemical Property of N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

Chemical Property:

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Technology Process of N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

There total 3 articles about N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 588-46-5
N-(phenylmethyl)acetamide

: 123076-73-3
N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) -78 deg C, 30 sec

2: 97 percent / triphenylphosphine, HN₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran; toluene / 24 h / -20 °C

3: 1.) hydrogen sulfide, triethylamine, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 100 min, 2.) CH₂Cl₂, room temperature, 12 h

With n-butyllithium; tris-(2-chloro-ethyl)-amine; hydrogen sulfide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jo00281a022

Reference yield:

: 2975-46-4
3-(trimethylsilyl)prop-2-yn-1-al

: 123076-73-3
N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) -78 deg C, 30 sec

2: 97 percent / triphenylphosphine, HN₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran; toluene / 24 h / -20 °C

3: 1.) hydrogen sulfide, triethylamine, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 100 min, 2.) CH₂Cl₂, room temperature, 12 h

With n-butyllithium; tris-(2-chloro-ethyl)-amine; hydrogen sulfide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jo00281a022

Reference yield:

: 123076-71-1
N-benzyl-3-hydroxy-5-(trimethylsilyl)pent-4-ynamide

: 123076-73-3
N-benzyl-3-<(tert-butoxycarbonyl)amino>-5-(trimethylsilyl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / triphenylphosphine, HN₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran; toluene / 24 h / -20 °C

2: 1.) hydrogen sulfide, triethylamine, 2.) triethylamine / 1.) CH₂Cl₂, 0 deg C, 100 min, 2.) CH₂Cl₂, room temperature, 12 h

With tris-(2-chloro-ethyl)-amine; hydrogen sulfide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jo00281a022