4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

Base Information

Chemical Name:4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline
CAS No.:1416850-60-6
Molecular Formula:C₂₈H₂₄N₄O₃S
Molecular Weight:496.59
Hs Code.:

Synonyms:4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

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Chemical Property of 4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

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Technology Process of 4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

There total 5 articles about 4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1416850-54-8
4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]aniline

: 1416850-60-6
4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

Guidance literature:: 4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]aniline; p-anisyl halide; With potassium tert-butylate; In toluene; for 0.5h; Inert atmosphere;

With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; Reflux; Inert atmosphere;
DOI:10.1002/ejoc.201200688

Reference yield:

: 1416850-47-9
5-(4-nitrophenyl)-2-(pyrazin-2-yl)thiazol-4-ol

: 1416850-60-6
4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.5 h

1.2: 24 h / 20 °C

2.1: hydrazine hydrate / ethanol / 50 °C

3.1: potassium tert-butylate / toluene / 0.5 h / Inert atmosphere

3.2: Reflux; Inert atmosphere

With potassium tert-butylate; hydrazine hydrate; potassium hydroxide; In ethanol; dimethyl sulfoxide; toluene; 3.1: |Buchwald-Hartwig Coupling / 3.2: |Buchwald-Hartwig Coupling;
DOI:10.1002/ejoc.201200688

Reference yield:

: 1416850-50-4
4-methoxy-5-(4-nitrophenyl)-2-(pyrazin-2-yl)thiazole

: 1416850-60-6
4-methoxy-N-{4-[4-methoxy-2-(pyrazin-2-yl)thiazol-5-yl]phenyl}-N-(4-methoxyphenyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 50 °C

2.1: potassium tert-butylate / toluene / 0.5 h / Inert atmosphere

2.2: Reflux; Inert atmosphere

With potassium tert-butylate; hydrazine hydrate; In ethanol; toluene; 2.1: |Buchwald-Hartwig Coupling / 2.2: |Buchwald-Hartwig Coupling;
DOI:10.1002/ejoc.201200688