α-azido bromomethyl-Phe-alcohol

Base Information

Chemical Name:α-azido bromomethyl-Phe-alcohol
CAS No.:474713-41-2
Molecular Formula:C₁₀H₁₂BrN₃O
Molecular Weight:270.129
Hs Code.:

Synonyms:α-azido bromomethyl-Phe-alcohol

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Chemical Property of α-azido bromomethyl-Phe-alcohol

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Technology Process of α-azido bromomethyl-Phe-alcohol

There total 4 articles about α-azido bromomethyl-Phe-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3-azido-1-bromo-4-phenylbutan-2-one

: 474713-41-2
α-azido bromomethyl-Phe-alcohol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; Inert atmosphere;
DOI:10.1039/b910611a

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 474713-41-2
α-azido bromomethyl-Phe-alcohol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / trifluoromethanesulfonyl azide; K₂CO₃; CuSO₄*5H₂O / methanol; CH₂Cl₂; H₂O / 20 °C

2.1: N-methylmorpholine / tetrahydrofuran / 0.25 h / -40 °C

3.1: aq. KOH / tetrahydrofuran; ethanol / 0 °C

3.2: aq. HBr / tetrahydrofuran; ethanol / 0.25 h / 0 °C

4.1: 350 mg / sodium borohydride / tetrahydrofuran; H₂O / 1 h / 20 °C

With 4-methyl-morpholine; potassium hydroxide; sodium tetrahydroborate; triflic azide; potassium carbonate; copper(II) sulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4020(02)00629-4

Reference yield:

: 79410-35-8
(2S)-2-azido-3-phenylpropanoic acid

: 474713-41-2
α-azido bromomethyl-Phe-alcohol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-methylmorpholine / tetrahydrofuran / 0.25 h / -40 °C

2.1: aq. KOH / tetrahydrofuran; ethanol / 0 °C

2.2: aq. HBr / tetrahydrofuran; ethanol / 0.25 h / 0 °C

3.1: 350 mg / sodium borohydride / tetrahydrofuran; H₂O / 1 h / 20 °C

With 4-methyl-morpholine; potassium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; ethanol; water;
DOI:10.1016/S0040-4020(02)00629-4