N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

Base Information

Chemical Name:N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane
CAS No.:190953-88-9
Molecular Formula:C₂₂H₂₆N₆
Molecular Weight:374.489
Hs Code.:

Synonyms:N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

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Chemical Property of N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

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Technology Process of N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

There total 3 articles about N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 190953-87-8
2-(phenylmethyl-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino)ethylcarbamic acid tert-butyl ester

: 190953-88-9
N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm980569z

Reference yield:

: 177948-00-4
3-(5-[1,2,4-triazol-4-yl]-1H-indol-3-yl)propan-1-ol

: 190953-88-9
N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeSO₂Cl, Et₃N, 2.) K₂CO₃, NaI / 1.) THF, 90 min, 2.) THF, i-PrOH, reflux, 9 h

2: 85 percent / AcOH, NaBH₃CN / methanol / 22 h / Ambient temperature

3: 83 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

With sodium cyanoborohydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium iodide; In methanol; dichloromethane;
DOI:10.1021/jm980569z

Reference yield:

: 190953-86-7
2-<3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propylamino>ethylcarbamic acid tert-butyl ester

: 190953-88-9
N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / AcOH, NaBH₃CN / methanol / 22 h / Ambient temperature

2: 83 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm980569z