(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one
CAS No.:251319-55-8
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

There total 4 articles about (R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 69152-87-0
4-benzyloxycrotonaldehyde

: 101711-78-8,131685-53-5
(3R)-3-propionyl-4-benzyloxazolidin-2-one

: 251319-55-8
(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; triethylamine; In dichloromethane; at -78 - 0 ℃;
DOI:10.1016/S0040-4039(99)01481-1

Reference yield:

: 69152-87-0
4-benzyloxycrotonaldehyde

: C₂₁H₃₂BNO₃

: 251319-55-8
(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

Guidance literature:: In dichloromethane; at -78 ℃; for 1h; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.080

Reference yield:

: 14593-43-2
benzyl allyl ether

: 251319-55-8
(R)-4-Benzyl-3-((E)-(2R,3S)-6-benzyloxy-3-hydroxy-2-methyl-hex-4-enoyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 12 h / 40 °C / Inert atmosphere

2: dichloromethane / 1 h / -78 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; 2: Evans aldol reaction;
DOI:10.1016/j.tet.2011.01.080