{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Base Information

Chemical Name:{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate
CAS No.:1273387-07-7
Molecular Formula:C₂₉H₃₃N₅O₇S₂
Molecular Weight:627.742
Hs Code.:

Synonyms:{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Suppliers and Price of {2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of {2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

There total 10 articles about {2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1273387-06-6
2-{2-[2-(benzyloxy)ethoxy]ethoxy}ethyl 2-({6-[(N-{[4-(1,3-thiazol-2-yl)phenyl]methyl}pyridine-2-sulfonamido)methyl]pyridin-2-yl}amino)acetate

: 1273387-07-7
{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: 2-{2-[2-(benzyloxy)ethoxy]ethoxy}ethyl 2-({6-[(N-{[4-(1,3-thiazol-2-yl)phenyl]methyl}pyridine-2-sulfonamido)methyl]pyridin-2-yl}amino)acetate; With trifluoroacetic acid; at 60 ℃; for 12h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1273387-07-7
{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: ethanol; calcium chloride; sodium tetrahydroborate / Tetraethylene glycol dimethyl ether / 35 °C / Cooling with ice

2.2: 1.17 h / 29 °C / Cooling with ice

3.1: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 22.5 h / 20 - 50 °C

6.1: trifluoroacetic acid / 12 h / 60 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; tributylphosphine; diamide; sodium hydride; potassium carbonate; trifluoroacetic acid; calcium chloride; In tetrahydrofuran; 1,4-dioxane; Tetraethylene glycol dimethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 454678-91-2
(4-(thiazol-2-yl)phenyl)methanol

: 1273387-07-7
{2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: triphenylphosphine; N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 20 °C

2: potassium carbonate / dichloromethane / 3 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: triethylamine / dichloromethane / 3 h / 20 °C

5: tributylphosphine; diamide / tetrahydrofuran / 12 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 50 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 22.5 h / 20 - 50 °C

8: trifluoroacetic acid / 12 h / 60 °C

With hydrogenchloride; N-Bromosuccinimide; tributylphosphine; diamide; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;