Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:143667-89-4
Molecular Formula:C₄₄H₅₁N₄O₆P
Molecular Weight:762.886
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 6 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 143632-19-3
1-<5-O--2-deoxy-β-D-ribofuranosyl>-4-phenylimidazole

: 143667-89-4
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 143667-89-4
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine / 6 h / 4 °C

2: 94 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 670-95-1
4-Phenylimidazole

: 143667-89-4
Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(4-phenyl-imidazol-1-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) CH₃CN, 0 degC, 40 min, 2.) CH₃CN, 3 h

2: 96 percent / 1percent methanol. NaOH / 1 h / Ambient temperature

3: 85 percent / pyridine / 6 h / 4 °C

4: 94 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; sodium hydroxide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;