1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

Base Information

Chemical Name:1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione
CAS No.:1393905-63-9
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

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Chemical Property of 1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

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Technology Process of 1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

There total 6 articles about 1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1393905-62-8
1-(2,3-bis(allyloxy)-4-methylphenyl)-3-morpholinopropane-1,3-dione

: 1393905-63-9
1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

Guidance literature:: With titanium tetrachloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -78 - 0 ℃; for 1.83333h;
DOI:10.1039/c2ob26035b

Reference yield:

: 1393905-59-3
methyl 2,3-dimethoxy-4-methylbenzoate

: 1393905-63-9
1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylsilyl iodide / dichloromethane / 23 h / Reflux

2.1: sulfuric acid / 18 h / 0 °C / Reflux

3.1: caesium carbonate / tetrahydrofuran / 15 h / Reflux

4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -10 °C

4.2: 1 h / -10 - 20 °C

5.1: titanium tetrachloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 1.83 h / -78 - 0 °C

With n-butyllithium; trimethylsilyl iodide; sulfuric acid; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; caesium carbonate; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c2ob26035b

Reference yield:

: 3929-89-3
2,3-dihydroxy-4-methylbenzoic acid

: 1393905-63-9
1-(3-(allyloxy)-2-hydroxy-4-methylphenyl)-3-morpholinopropane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 18 h / 0 °C / Reflux

2.1: caesium carbonate / tetrahydrofuran / 15 h / Reflux

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -10 °C

3.2: 1 h / -10 - 20 °C

4.1: titanium tetrachloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 1.83 h / -78 - 0 °C

With n-butyllithium; sulfuric acid; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; caesium carbonate; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/c2ob26035b