(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Base Information

Chemical Name:(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane
CAS No.:350237-04-6
Molecular Formula:C₂₅H₃₇NOSi
Molecular Weight:395.66
Hs Code.:

Synonyms:(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Suppliers and Price of (2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

There total 9 articles about (2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1086510-50-0
C₂₅H₃₅NOSi

: 350237-04-6
(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Guidance literature:: With 10% Pd/C; hydrogen; In methanol; for 8h; under 3102.97 Torr;
DOI:10.1021/jo801653c

Reference yield:

: 350237-03-5
(2R,4R)-2-(tert-butyldiphenylsilyloxy)-8-nonen-4-amine

: 350237-04-6
(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Guidance literature:: With Cp*2NdCH(SiMe₃)2; In benzene-d6; at 20 ℃;
DOI:10.1021/jo015603n

Reference yield:

: 7766-48-5
1-iodo-4-pentene

: 350237-04-6
(2R,2'R,6'R)-(-)-1-(6'-methylpiperidin-2'-yl)-2-(tert-butyldiphenylsilyloxy)propane

Guidance literature:: Multi-step reaction with 7 steps

1: n-BuLi / hexane / -50 - 0 °C

2: imidazole / dimethylformamide

3: H₂O; HgCl₂; CdCO₃ / acetonitrile / 50 - 60 °C

4: aq.NaBH₄ / methanol / -78 - 20 °C

5: PPh₃; DEAD / tetrahydrofuran / 20 °C

6: 72 percent / NaBH₄ / propan-2-ol; H₂O / 20 °C

7: 63.6 mg / Cp*2NdCH(TMS)2 / benzene-d6 / 20 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; cadmium(II) carbonate; Cp*2NdCH(SiMe₃)2; water; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; benzene-d6; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 5: Mitsunobu reaction;
DOI:10.1021/jo015603n