1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

Base Information

Chemical Name:1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride
CAS No.:1345962-07-3
Molecular Formula:C₂₀H₂₀BrFN₂O₃*ClH
Molecular Weight:471.754
Hs Code.:

Synonyms:1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

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Chemical Property of 1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

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Technology Process of 1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

There total 3 articles about 1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345962-16-4
1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

: 1345962-07-3
1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 1245716-02-2
N-[(toluene-4-sulfonyl)-(3-bromo-4,5-dimethoxyphenyl)methyl]formamide

: 1345962-07-3
1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / -10 - -5 °C

2.1: acetic acid / ethanol / 2 h / Reflux

2.2: 5 h / Reflux

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; acetic acid; triethylamine; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 1257227-16-9
3-bromo-4,5-dimethoxyphenyl(tosyl)methyl isocyanide

: 1345962-07-3
1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 2 h / Reflux

1.2: 5 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.17 h / 20 °C

With hydrogenchloride; acetic acid; In 1,4-dioxane; ethanol; dichloromethane;