C₃₇H₄₈O₇

Base Information

Chemical Name:C₃₇H₄₈O₇
CAS No.:236746-20-6
Molecular Formula:C₃₇H₄₈O₇
Molecular Weight:604.784
Hs Code.:

C<sub>37</sub>H<sub>48</sub>O<sub>7</sub>

Synonyms:C₃₇H₄₈O₇

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Chemical Property of C₃₇H₄₈O₇

Chemical Property:

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Technology Process of C₃₇H₄₈O₇

There total 36 articles about C₃₇H₄₈O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 172906-75-1
2-methyl-2-propen-1-yl diazoacetate

: 236746-20-6
C₃₇H₄₈O₇

Guidance literature:: Multi-step reaction with 29 steps

1: 62 percent / <(R,R)-bis2O-)>-C(CH₃)2>*CuOTf / CHCl₃ / Ambient temperature

2: 1.) MeAl / 1.) toluene, from 0 deg C to RT, 30 min, 2.) toluene, RT, 30 min

3: 92 percent / N-methylmorpholine-N-oxide, tetra-n-propylammonium perruthenate, 4 Angstroem sieves / CH₂Cl₂; acetonitrile / 0.5 h / Ambient temperature

4: 1.) potassium hexamethyldisilazide / 1.) toluene, THF, from 0 deg C to RT, 30 min, 2.) toluene, THF, from -78 deg C to 0 deg C, 1 h

5: 1.) t-BuLi / 1.) ether, -78 deg C, 2.) ether

6: Et₃N / -25 °C

7: 24 h / 110 °C

8: aq. HCl

9: 90 percent / tetrahydrofuran / 0 °C

10: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

11: 1.) Red-Al, 2.) N-iodosuccinimide / 1.) Et₂O, 23 deg C, 2.) Et₂O, from -78 deg C to 23 deg C

12: 97 percent / imidazole / dimethylformamide

13: Pd(OAc)2, Ph₃P, Ag₂CO₃ / tetrahydrofuran / Heating

14: tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

15: 95 percent / N-methylmorpholin-N-oxide, tetra-n-propylammonium perruthenate

16: 1.) LiBr, Ni(acac)2 / 1.) Et₂O, 0 deg C, 10 min, 2.) Et₂O, RT, 17 h

17: 2-methoxy-1,3-dioxolane, Amberlyst-15 acidic resin / acetonitrile / 12 h / Ambient temperature

18: m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

19: LiAlH₄ / diethyl ether; tetrahydrofuran / 14 h / Ambient temperature

20: 20 percent aq. HCl / tetrahydrofuran / 12 h / 50 °C

21: N,N-diisopropylethylamine / CH₂Cl₂ / 7 h / Ambient temperature

22: 2.) Et₃N / 1.) toluene, THF, 0 deg C, 10 h, 2.) THF, from 0 deg C to RT

23: 1M aq. HCl / tetrahydrofuran / 0.25 h / Ambient temperature

24: LiAlH₄ / tetrahydrofuran / 0.5 h / -78 °C

25: pyridine, DMAP / CH₂Cl₂ / 2 h / 0 °C

26: 1.) LDA / 1.) hexane, THF, 0 deg C, 15 min, 2.) hexane, THF, 0 deg C, 2 h

27: K₂CO₃, KOH / methanol / 24 h / 140 °C

28: diethyl ether / 0.5 h / 0 °C

29: DMAP, pyridine / 5 h / 100 °C

With 2-methoxy-1,3-dioxolane; pyridine; 1H-imidazole; hydrogenchloride; dmap; palladium diacetate; bis(acetylacetonate)nickel(II); potassium hydroxide; N-iodo-succinimide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; <(R,R)-bis-C(CH3)2>*CuOTf; 4 A molecular sieve; Amberlyst-15 acidic resin; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; silver carbonate; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja990404v

Reference yield:

: 169532-07-4
(1S,5R)-5-methyl-2-oxo-3-oxabicyclo<3.1.0>hexane

: 236746-20-6
C₃₇H₄₈O₇

Guidance literature:: Multi-step reaction with 28 steps

1: 1.) MeAl / 1.) toluene, from 0 deg C to RT, 30 min, 2.) toluene, RT, 30 min

2: 92 percent / N-methylmorpholine-N-oxide, tetra-n-propylammonium perruthenate, 4 Angstroem sieves / CH₂Cl₂; acetonitrile / 0.5 h / Ambient temperature

3: 1.) potassium hexamethyldisilazide / 1.) toluene, THF, from 0 deg C to RT, 30 min, 2.) toluene, THF, from -78 deg C to 0 deg C, 1 h

4: 1.) t-BuLi / 1.) ether, -78 deg C, 2.) ether

5: Et₃N / -25 °C

6: 24 h / 110 °C

7: aq. HCl

8: 90 percent / tetrahydrofuran / 0 °C

9: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

10: 1.) Red-Al, 2.) N-iodosuccinimide / 1.) Et₂O, 23 deg C, 2.) Et₂O, from -78 deg C to 23 deg C

11: 97 percent / imidazole / dimethylformamide

12: Pd(OAc)2, Ph₃P, Ag₂CO₃ / tetrahydrofuran / Heating

13: tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

14: 95 percent / N-methylmorpholin-N-oxide, tetra-n-propylammonium perruthenate

15: 1.) LiBr, Ni(acac)2 / 1.) Et₂O, 0 deg C, 10 min, 2.) Et₂O, RT, 17 h

16: 2-methoxy-1,3-dioxolane, Amberlyst-15 acidic resin / acetonitrile / 12 h / Ambient temperature

17: m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

18: LiAlH₄ / diethyl ether; tetrahydrofuran / 14 h / Ambient temperature

19: 20 percent aq. HCl / tetrahydrofuran / 12 h / 50 °C

20: N,N-diisopropylethylamine / CH₂Cl₂ / 7 h / Ambient temperature

21: 2.) Et₃N / 1.) toluene, THF, 0 deg C, 10 h, 2.) THF, from 0 deg C to RT

22: 1M aq. HCl / tetrahydrofuran / 0.25 h / Ambient temperature

23: LiAlH₄ / tetrahydrofuran / 0.5 h / -78 °C

24: pyridine, DMAP / CH₂Cl₂ / 2 h / 0 °C

25: 1.) LDA / 1.) hexane, THF, 0 deg C, 15 min, 2.) hexane, THF, 0 deg C, 2 h

26: K₂CO₃, KOH / methanol / 24 h / 140 °C

27: diethyl ether / 0.5 h / 0 °C

28: DMAP, pyridine / 5 h / 100 °C

With 2-methoxy-1,3-dioxolane; pyridine; 1H-imidazole; hydrogenchloride; dmap; palladium diacetate; bis(acetylacetonate)nickel(II); potassium hydroxide; N-iodo-succinimide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4 A molecular sieve; Amberlyst-15 acidic resin; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; silver carbonate; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja990404v

Reference yield:

: 236745-39-4
(1S,2R)-1-(N,O-dimethylhydroxamido)-2-formyl-2-methylcyclopropane

: 236746-20-6
C₃₇H₄₈O₇

Guidance literature:: Multi-step reaction with 26 steps

1: 1.) potassium hexamethyldisilazide / 1.) toluene, THF, from 0 deg C to RT, 30 min, 2.) toluene, THF, from -78 deg C to 0 deg C, 1 h

2: 1.) t-BuLi / 1.) ether, -78 deg C, 2.) ether

3: Et₃N / -25 °C

4: 24 h / 110 °C

5: aq. HCl

6: 90 percent / tetrahydrofuran / 0 °C

7: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

8: 1.) Red-Al, 2.) N-iodosuccinimide / 1.) Et₂O, 23 deg C, 2.) Et₂O, from -78 deg C to 23 deg C

9: 97 percent / imidazole / dimethylformamide

10: Pd(OAc)2, Ph₃P, Ag₂CO₃ / tetrahydrofuran / Heating

11: tetrabutylammonium fluoride / tetrahydrofuran / 23 °C

12: 95 percent / N-methylmorpholin-N-oxide, tetra-n-propylammonium perruthenate

13: 1.) LiBr, Ni(acac)2 / 1.) Et₂O, 0 deg C, 10 min, 2.) Et₂O, RT, 17 h

14: 2-methoxy-1,3-dioxolane, Amberlyst-15 acidic resin / acetonitrile / 12 h / Ambient temperature

15: m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

16: LiAlH₄ / diethyl ether; tetrahydrofuran / 14 h / Ambient temperature

17: 20 percent aq. HCl / tetrahydrofuran / 12 h / 50 °C

18: N,N-diisopropylethylamine / CH₂Cl₂ / 7 h / Ambient temperature

19: 2.) Et₃N / 1.) toluene, THF, 0 deg C, 10 h, 2.) THF, from 0 deg C to RT

20: 1M aq. HCl / tetrahydrofuran / 0.25 h / Ambient temperature

21: LiAlH₄ / tetrahydrofuran / 0.5 h / -78 °C

22: pyridine, DMAP / CH₂Cl₂ / 2 h / 0 °C

23: 1.) LDA / 1.) hexane, THF, 0 deg C, 15 min, 2.) hexane, THF, 0 deg C, 2 h

24: K₂CO₃, KOH / methanol / 24 h / 140 °C

25: diethyl ether / 0.5 h / 0 °C

26: DMAP, pyridine / 5 h / 100 °C

With 2-methoxy-1,3-dioxolane; pyridine; 1H-imidazole; hydrogenchloride; dmap; palladium diacetate; bis(acetylacetonate)nickel(II); potassium hydroxide; N-iodo-succinimide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; Amberlyst-15 acidic resin; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; silver carbonate; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja990404v