(5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione

Base Information

• Chemical Name: (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione
• CAS No.: 244241-91-6
• Molecular Formula: C₃₂H₂₉ClN₂O₄S
• Molecular Weight: 573.112
• Mol file: 244241-91-6.mol

Synonyms:(5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione

Chemical Property of (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione

There total 3 articles about (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanone (244241-90-5) → (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione (244241-91-6)

Guidance literature:

With Lawessons reagent; In benzene; at 80 ℃; for 1.5h;

DOI:10.1021/jo990452y

Reference yield:

5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole (128300-12-9) → (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione (244241-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / ethyl acetate

2: 53 percent / EDCI

3: 88 percent / (p-MeOPhPS₂)2 / benzene / 1.5 h / 80 °C

With Lawessons reagent; hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; benzene;

DOI:10.1021/jo990452y

Reference yield:

5-benzyloxy-1-chloromethyl-2,3-dihydro-1H-benzo[e]indole; hydrochloride → (5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanethione (244241-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / EDCI

2: 88 percent / (p-MeOPhPS₂)2 / benzene / 1.5 h / 80 °C

With Lawessons reagent; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In benzene;

DOI:10.1021/jo990452y

upstream raw materials:

(5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-(5,6,7-trimethoxy-1H-indol-2-yl)-methanone

5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole

Downstream raw materials:

C-(5-benzyloxy-1-chloromethyl-1,2-dihydro-benzo[e]indol-3-yl)-C-(5,6,7-trimethoxy-1H-indol-2-yl)-methyleneamine