2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

Base Information

Chemical Name:2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile
CAS No.:1345960-02-2
Molecular Formula:C₁₇H₁₁F₂N₃OS
Molecular Weight:343.357
Hs Code.:

Synonyms:2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

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Chemical Property of 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

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Technology Process of 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

There total 6 articles about 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345961-01-4
5-chloro-1-[(2,2-difluorocyclopropyl)methyl][1,3]thiazolo[5,4-b]pyridin-2(1H)-one

: 138642-62-3
2-Cyanophenylboronic acid

: 1345960-02-2
2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

Guidance literature:: With caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1345961-00-3
5-chloro-2-methoxy[1,3]thiazolo[5,4-b]pyridine

: 1345960-02-2
2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: water / hydrogenchloride / 1,4-dioxane / 0.33 h / 95 °C / oil bath; Inert atmosphere

2: caesium carbonate / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 18 h / 95 °C / oil bath

3: caesium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 100 °C / Microwave irradiation

With water; caesium carbonate; hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 121879-69-4
5-chloro-1H-thiazolo[5,4-b]pyridin-2-one

: 1345960-02-2
2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 18 h / 95 °C / oil bath

2: caesium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 100 °C / Microwave irradiation

With caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;