(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Base Information

Chemical Name:(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one
CAS No.:725253-49-6
Molecular Formula:C₅₄H₆₆O₁₂
Molecular Weight:907.111
Hs Code.:

(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Synonyms:(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Suppliers and Price of (2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

There total 19 articles about (2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 725253-61-2
(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-decahydro-1,6-dioxa-cycloheptacycloocten-3-ol

: 725253-49-6
(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Guidance literature:: With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 252046-22-3
(2R,3R,4S,4aS,9aS)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-2,3,4,4a,9,9a-hexahydro-6H-pyrano[3,2-b]oxepin

: 725253-49-6
(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: AD-mix β; MeSO2NH2 / 2-methyl-propan-2-ol; H2O; various solvent(s) / 0 °C

2.1: CSA / CH₂Cl₂ / 20 °C

3.1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

4.1: CSA / CH₂Cl₂ / 20 °C

5.1: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

6.1: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

7.1: 92 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

8.1: 99 percent / NaH / dimethylformamide / 0 - 20 °C

9.1: 9-BBN / tetrahydrofuran / 20 °C

9.2: aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

10.1: thexylborane / tetrahydrofuran / 0 °C

10.2: 78 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

11.1: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; tetrapropylammonium perruthennate; methanesulfonamide; 4 A molecular sieve; thexylborane; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; 1,4-bis(9-O-dihydroquinidine)phthalazine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 9.1: Suzuki-Miyaura coupling / 9.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2004.04.083

Reference yield:

: 725253-39-4
(3aS,4aS,6R,7R,8R,8aS,10aR)-7,8-Bis-benzyloxy-6-benzyloxymethyl-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulene

: 725253-49-6
(2S,5aS,7R,8S,11aR)-8-Benzyloxy-2-[(3aS,4aS,6R,7R,8S,8aS,10aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2,2-dimethyl-octahydro-1,3,5,9-tetraoxa-benzo[f]azulen-6-ylmethyl]-7-benzyloxymethyl-octahydro-1,6-dioxa-cycloheptacycloocten-3-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

2.1: CSA / CH₂Cl₂ / 20 °C

3.1: 92 percent / KOt-Bu; n-Bu₄NI / tetrahydrofuran / 20 °C

4.1: 100 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

5.1: 92 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 20 °C

6.1: 99 percent / NaH / dimethylformamide / 0 - 20 °C

7.1: 9-BBN / tetrahydrofuran / 20 °C

7.2: aq. Cs₂CO₃ / PdCl₂(dppf)*CH₂Cl₂ / tetrahydrofuran; dimethylformamide / 50 °C

8.1: thexylborane / tetrahydrofuran / 0 °C

8.2: 78 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 20 °C

9.1: TPAP; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; thexylborane; camphor-10-sulfonic acid; potassium tert-butylate; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 7.1: Suzuki-Miyaura coupling / 7.2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2004.04.083