(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Base Information

Chemical Name:(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene
CAS No.:401796-85-8
Molecular Formula:C₅₀H₄₆N₄O₃
Molecular Weight:750.94
Hs Code.:

Synonyms:(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Suppliers and Price of (-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

There total 3 articles about (-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 183004-20-8
(-)-(1S,4R)-1-hydroxymethyl-4-[(6'-aminopyrimidine-4'-yl)amino]cyclopent-2-ene

: 14470-28-1
mono-4-methoxytrityl chloride

: 401796-85-8
(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1023/A:1012348515833

Reference yield:

: 136522-35-5
(1R,4S)-1-amino-4-hydroxymethyl-2-cyclopentene

: 401796-85-8
(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / diisopropylethylamine / butan-1-ol / 1 h / Heating

2: 80 percent / ammonia / methanol / 18 h / 180 °C

3: 72 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

With ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; butan-1-ol;
DOI:10.1023/A:1012348515833

Reference yield:

: 401796-83-6
(-)-(1S,4R)-1-hydroxymethyl-4-[(6'-chloropyrimidine-4'-yl)amino]cyclopent-2-ene

: 401796-85-8
(-)-(1S,4R)-1-monomethoxytrityloxymethyl-4-[(6'-monomethoxytritylaminopyrimidine-4'-yl)amino]cyclopent-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / ammonia / methanol / 18 h / 180 °C

2: 72 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

With ammonia; triethylamine; In methanol; dichloromethane;
DOI:10.1023/A:1012348515833