(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:193686-73-6
Molecular Formula:C₁₇H₁₈ClNO₃S
Molecular Weight:351.854
Hs Code.:

Synonyms:(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Property:

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Technology Process of (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 1 articles about (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 193686-76-9
7-chloro-1-(4-methylbenzenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 193686-73-6
(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at 4 ℃; for 18h;
DOI:10.3987/COM-00-S(K)4

Reference yield: 92.0%

: 107-30-2
chloromethyl methyl ether

: 193686-73-6
(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 331947-51-4
(S)-7-chloro-5-methoxymethyloxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

chloromethyl methyl ether; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.3987/COM-99-S(I)2

Reference yield:

: 193686-73-6
(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 331947-44-5
(-)-Tolvaptan

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 92 percent / dimethylformamide / 18 h / 20 °C

2.1: 74 percent / magnesium / methanol / 2 h / Heating

3.1: pyridine / CH₂Cl₂ / 2 h / 20 °C

4.1: 74 percent / conc. HCl / methanol / 1.5 h / 55 °C

With pyridine; hydrogenchloride; sodium hydride; magnesium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-99-S(I)2