(2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Base Information

• Chemical Name: (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester
• CAS No.: 96922-04-2
• Molecular Formula: C₄₆H₅₉N₅O₁₃
• Molecular Weight: 890

Synonyms:(2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Chemical Property of (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

There total 4 articles about (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-Amino-2-benzyloxycarbonylamino-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester (96922-03-1) + Boc-L-Ala-D-Glu(OH)OBzl (50515-48-5,60209-60-1,80935-23-5) → (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester (96922-04-2)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; In acetonitrile; Ambient temperature;

DOI:10.1248/cpb.33.889

Reference yield:

2-Benzyloxycarbonylamino-5-(2,5-dioxo-oxazolidin-4-yl)-pentanoic acid ethyl ester (82876-54-8) → (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester (96922-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / -20 - -10 °C

2: 77 percent / N-hydroxysuccinimide / acetonitrile / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1248/cpb.33.889

Reference yield:

2,6-Bis-benzyloxycarbonylamino-6-hydrazinocarbonyl-hexanoic acid (25612-42-4,76489-94-6) → (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester (96922-04-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / N-chlorosuccinimide / CH₂Cl₂ / -5 °C

2: SOCl₂ / CH₂Cl₂

3: Et₃N / CH₂Cl₂ / -20 - -10 °C

4: 77 percent / N-hydroxysuccinimide / acetonitrile / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; N-chloro-succinimide; thionyl chloride; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1248/cpb.33.889

upstream raw materials:

6-Amino-2-benzyloxycarbonylamino-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Boc-L-Ala-D-Glu(OH)OBzl

2-Benzyloxycarbonylamino-5-(2,5-dioxo-oxazolidin-4-yl)-pentanoic acid ethyl ester

2,6-Bis-benzyloxycarbonylamino-6-hydrazinocarbonyl-hexanoic acid

Downstream raw materials:

(2S,6S)-6-[(S)-4-((R)-2-Amino-propionylamino)-4-benzyloxycarbonyl-butyrylamino]-2-benzyloxycarbonylamino-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

(2S,6S)-2-Benzyloxycarbonylamino-6-(benzyloxycarbonylmethyl-carbamoyl)-6-{(S)-4-benzyloxycarbonyl-4-[(R)-2-((2R,3R,4R,5S)-2,3,4,5,6-pentaacetoxy-hexanoylamino)-propionylamino]-butyrylamino}-hexanoic acid ethyl ester

(2S,6S)-2-Benzyloxycarbonylamino-6-{(S)-4-benzyloxycarbonyl-4-[(R)-2-((S)-2-hydroxy-2-phenyl-acetylamino)-propionylamino]-butyrylamino}-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

(2S,6S)-6-{(S)-4-[(R)-2-(2-Acetoxy-acetylamino)-propionylamino]-4-benzyloxycarbonyl-butyrylamino}-2-benzyloxycarbonylamino-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 96922-04-2 (2S,6S)-2-Benzyloxycarbonylamino-6-[(S)-4-benzyloxycarbonyl-4-((R)-2-tert-butoxycarbonylamino-propionylamino)-butyrylamino]-6-(benzyloxycarbonylmethyl-carbamoyl)-hexanoic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send