tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

Base Information

Chemical Name:tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate
CAS No.:854372-23-9
Molecular Formula:C₃₁H₃₃NO₇S
Molecular Weight:563.672
Hs Code.:

Synonyms:tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

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Chemical Property of tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

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Technology Process of tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

There total 5 articles about tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 854372-00-2
tert-butyl N-[(4'-hydroxy-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

: 24673-56-1
3-methyl-1-benzofuran-2-carboxylic acid

: 854372-23-9
tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2005.07.076

Reference yield:

: 779341-90-1
(R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester

: 854372-23-9
tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

2: 71 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.076

Reference yield:

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 854372-23-9
tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 8 h / 90 °C

2: 71 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; potassium carbonate; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2005.07.076