(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

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Chemical Name:(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal
CAS No.:692749-42-1
Molecular Formula:C₃₀H₅₄O₅Si₂
Molecular Weight:550.927
Hs Code.:

Synonyms:(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

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Chemical Property of (E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

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Technology Process of (E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

There total 6 articles about (E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 727985-23-1
(E)-(3S,4S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-5,7-dimethyl-oct-5-ene-1,2-diol

: 692749-42-1
(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

Guidance literature:: With sodium periodate;
DOI:10.1002/anie.200353348

Reference yield:

: 220213-54-7
(E)-(R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-en-1-ol

: 692749-42-1
(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 2-iodylbenzoic acid

2: 93 percent / Bu₂BOTf; Et₃N

3: LiBH₄

4: 95 percent / OsO₄; 4-methylmorpholine 4-oxide

5: 84 percent / NaIO₄

With sodium periodate; osmium(VIII) oxide; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; 2-iodoxybenzoic acid; 4-methylmorpholine N-oxide; triethylamine; 2: Evans aldol reaction;
DOI:10.1002/anie.200353348

Reference yield:

: 692749-33-0
(S)-3-[(E)-(2S,3S,6R)-3-Hydroxy-7-(4-methoxy-benzyloxy)-4,6-dimethyl-2-vinyl-hept-4-enoyl]-4-isopropyl-oxazolidin-2-one

: 692749-42-1
(E)-(2R,3S,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-hept-4-enal

Guidance literature:: Multi-step reaction with 5 steps

1: LiBH₄

2: 95 percent / OsO₄; 4-methylmorpholine 4-oxide

3: 84 percent / NaIO₄

With sodium periodate; osmium(VIII) oxide; lithium borohydride; 4-methylmorpholine N-oxide;
DOI:10.1002/anie.200353348