4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

Base Information

Chemical Name:4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester
CAS No.:608537-07-1
Molecular Formula:C₂₉H₂₃FO₈
Molecular Weight:518.495
Hs Code.:

Synonyms:4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

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Chemical Property of 4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

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Technology Process of 4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

There total 6 articles about 4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 33560-65-5
oxalic acid tert-butyl ester methyl ester

: 608536-98-7
1-{3-[(3-acetylphenyl)(2-fluorophenyl)methyl]phenyl}ethanone

: 608537-07-1
4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

Guidance literature:: With sodium methylate; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; at 20 ℃; for 2h;
DOI:10.1021/jm030559k

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 608537-07-1
4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 2.5 h / -70 °C

1.2: 95 percent / hexane; tetrahydrofuran / -78 - 20 °C

2.1: 98.6 percent / Jones reagent / acetone / 0.42 h / 0 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 3.5 h / -70 °C

3.2: 95 percent / hexane; tetrahydrofuran / -50 - 20 °C

4.1: 100 percent / NaI; Me₂SiCl₂ / acetonitrile / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

5.2: 40.2 percent / tetrahydrofuran; hexane / 2 h / -50 °C

6.1: 85 percent / NaOMe / toluene; 1,2-dimethoxy-ethane; tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; jones reagent; sodium methylate; dimethylsilicon dichloride; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; acetone; toluene; acetonitrile;
DOI:10.1021/jm030559k

Reference yield:

: 698982-09-1
(3-bromophenyl)(2-fluorophenyl)methanol

: 608537-07-1
4-(3-{(2-fluorophenyl)[3-(3-methoxycarbonyl-3-oxopropionyl)phenyl]methyl}phenyl)-2,4-dioxobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98.6 percent / Jones reagent / acetone / 0.42 h / 0 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 3.5 h / -70 °C

2.2: 95 percent / hexane; tetrahydrofuran / -50 - 20 °C

3.1: 100 percent / NaI; Me₂SiCl₂ / acetonitrile / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

4.2: 40.2 percent / tetrahydrofuran; hexane / 2 h / -50 °C

5.1: 85 percent / NaOMe / toluene; 1,2-dimethoxy-ethane; tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; jones reagent; sodium methylate; dimethylsilicon dichloride; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; acetone; toluene; acetonitrile;
DOI:10.1021/jm030559k