2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Base Information

• Chemical Name: 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• CAS No.: 862080-97-5
• Molecular Formula: C₃₃H₅₀N₂O₉SSi₂
• Molecular Weight: 707.005

Synonyms:2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Chemical Property of 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

There total 5 articles about 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ4-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-84-0) + O,O'-bis-(trimethylsilyl)uracil (10457-14-4) → (1R,2S,5S,11S)-7,7,9,9-Tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-ene 2-oxide + 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-97-5)

Guidance literature:

With triethylamine; In dichloromethane; toluene; at 20 ℃; for 0.0833333h;

DOI:10.1021/jo0506985

Reference yield:

C11H18O3S (849112-79-4) → 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-97-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 91 percent / aq. HCl / tetrahydrofuran / 8 h / 20 °C

2.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

3.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

3.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

4.1: 75 percent / Davis oxaziridine reagent / CHCl₃ / 4 h / 0 °C

5.1: 30 percent / Et₃N / CH₂Cl₂; toluene / 0.08 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; Davis oxaziridine reagent; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene; 5.1: Pummerer reaction;

DOI:10.1021/jo0506985

Reference yield:

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol (862080-75-9) → 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-97-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

2.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

2.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

3.1: 75 percent / Davis oxaziridine reagent / CHCl₃ / 4 h / 0 °C

4.1: 30 percent / Et₃N / CH₂Cl₂; toluene / 0.08 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; Davis oxaziridine reagent; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene; 4.1: Pummerer reaction;

DOI:10.1021/jo0506985

upstream raw materials:

2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

O,O'-bis-(trimethylsilyl)uracil

C₁₁H₁₈O₃S

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 862080-97-5 2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send