4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

Base Information

Chemical Name:4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile
CAS No.:864361-81-9
Molecular Formula:C₂₂H₃₁ClN₂O₃Si
Molecular Weight:435.038
Hs Code.:

Synonyms:4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

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Chemical Property of 4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

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Technology Process of 4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

There total 11 articles about 4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864361-80-8
2-(3-chloro-4-cyano-2-methylphenyl)acetic acid

: 757247-72-6
(2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilanyloxy)-2-(1-hydroxyethyl)-pyrrolidine

: 864361-81-9
4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: (2S,3S)-N-tert-butyloxycarbonyl-3-(tert-butyldimethylsilanyloxy)-2-(1-hydroxyethyl)-pyrrolidine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

2-(3-chloro-4-cyano-2-methylphenyl)acetic acid; With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: C₁₈H₃₇NO₄Si

: 864361-81-9
4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 4-methyl morpholine N-oxide / tetrapropylammonium perruthenate / acetonitrile; CH₂Cl₂ / 2 h / 20 °C

2: TFA / CH₂Cl₂ / 4 h / 20 °C

3: 220 mg / PyBroP; i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm070312d

Reference yield:

: 864361-80-8
2-(3-chloro-4-cyano-2-methylphenyl)acetic acid

: C₁₃H₂₇NO₂Si

: 864361-81-9
4-(2-((2S,3S)-2-Acetyl-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)-2-oxoethyl)-2-chloro-3-methylbenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm070312d