1,6,20,25-TETRAAZA[6.1.6.1]PARACYCLOPHANE

Base Information

• Chemical Name: 1,6,20,25-TETRAAZA[6.1.6.1]PARACYCLOPHANE
• CAS No.: 74043-83-7
• Molecular Formula: C34H40 N4
• Molecular Weight: 504.718
• Mol file: 74043-83-7.mol

Synonyms:CPM 44

Chemical Property of 1,6,20,25-TETRAAZA[6.1.6.1]PARACYCLOPHANE

Chemical Property:

• Melting Point: 183 °C
• PSA: 48.12000
• LogP: 8.34200

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,6,20,25-Tetraaza[6.1.6.1]paracyclophane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,6,20,25-Tetraaza[6.1.6.1]paracyclophane (CAS# 74043-83-7) is a tetraazaparacyclophane derivative, commonly substituted for enhanced water solubility to allow for the formation of inclusion complexes.

Technology Process of 1,6,20,25-TETRAAZA[6.1.6.1]PARACYCLOPHANE

There total 5 articles about 1,6,20,25-TETRAAZA[6.1.6.1]PARACYCLOPHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(S,S,S,S)-(-)-3,4,22,23-tetramethoxy-1,6,20,25-tetrakis(p-toluenesulfonyl)-1,6,20,25-tetraaza[6.1.6.1]paracyclophane → 1,6,20,25-tetraaza[6.1.6.1]paracyclophane (74043-83-7)

Guidance literature:

With sulfuric acid; 1.) RT, 18 h, 2.) 50 deg C, 3 h;

Reference yield: 67.0%

N,N',N'',N'''-tetratosyl-1,6,20,25-tetraaza[6.1.6.1]paracyclophane (74043-80-4) → 1,6,20,25-tetraaza[6.1.6.1]paracyclophane (74043-83-7)

Guidance literature:

DOI:10.1021/ja00527a083

Reference yield:

4,4’-methylenebis(N-p-tosylanilide) (74043-79-1) → 1,6,20,25-tetraaza[6.1.6.1]paracyclophane (74043-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / K₂CO₃ / dimethylformamide / Ambient temperature

2: 67 percent / 47percent aq. HBr, phenol / 2 h / Heating

With hydrogen bromide; potassium carbonate; phenol; In N,N-dimethyl-formamide;

DOI:10.1021/jo00223a013

upstream raw materials:

N,N',N'',N'''-tetratosyl-1,6,20,25-tetraaza[6.1.6.1]paracyclophane

4,4’-methylenebis(N-p-tosylanilide)

N,N'-bis(p-tosyl)-N,N'-bis(4-bromobutyl)-p,p'-diaminodiphenylmethane

C₃₉H₄₈I₂N₂O₈S₂

Downstream raw materials:

C₃₄H₄₀N₄*C₁₆H₁₃NO₃S

C₃₄H₄₀N₄*C₁₀H₁₄*4ClH

C₃₄H₄₀N₄*C₆H₆O₃S