[2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide

Base Information

• Chemical Name: [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide
• CAS No.: 325458-33-1
• Molecular Formula: C₂₀H₂₂N₂O₃
• Molecular Weight: 338.406
• Mol file: 325458-33-1.mol

Synonyms:[2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide

Chemical Property of [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide

There total 5 articles about [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S-cis)-2-(2-methyl-1-propenyl)-4,N-diphenyl-3-oxazolidinecarboxamide (298210-06-7) → [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide (325458-33-1)

Guidance literature:

With DMd; In acetone; at 20 ℃;

DOI:10.1021/ol006800w

Reference yield:

(2S-cis)-2-(2-methyl-1-propenyl)-4,N-diphenyl-3-oxazolidinecarboxamide (298210-06-7) → [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide (325458-33-1) + [2S-[2α(S*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform-d1;

DOI:10.1021/ol006800w

Reference yield:

3,3-dimethyl acrylaldehyde (107-86-8) → [2S-[2α(R*),4α]]-2-(3,3-dimethyloxiranyl)-4,N-diphenyl-3-oxazolidinecarboxamide (325458-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: molecular sieves 4 Angstroem / CH₂Cl₂ / 3 h / 20 °C

2: 1.78 g / CH₂Cl₂; diethyl ether / 16 h / 20 °C

3: 89 percent / dimethyldioxirane / acetone / 5 h / 20 °C

With 4 A molecular sieve; 3,3-dimethyldioxirane; In diethyl ether; dichloromethane; acetone;

DOI:10.1021/ja010463k

upstream raw materials:

(2S-cis)-2-(2-methyl-1-propenyl)-4,N-diphenyl-3-oxazolidinecarboxamide

3,3-dimethyl acrylaldehyde

(2S)-2-phenylglycinol