4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

Base Information

Chemical Name:4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl
CAS No.:1365543-42-5
Molecular Formula:C₂₄H₂₇N₄O₃
Molecular Weight:419.503
Hs Code.:

Synonyms:4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

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Chemical Property of 4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

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Technology Process of 4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

There total 6 articles about 4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1365543-41-4
4-{[4-(5-{[(1-methoxy-1-methyl)amino]carbonyl}benzimidazol-2-yl)benzoyl]amino}-2,2,6,6-tetramethylpiperidin-1-oxyl

: 1365543-42-5
4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 19h;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 1365543-42-5
4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

3: 5%-palladium/activated carbon; hydrogen / methanol / 40 h / 20 °C

4: sodium metabisulfite / ethanol; water / 6 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sodium metabisulfite; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.042

Reference yield:

: 24376-18-9
3,4-dinitrobenzoyl chloride

: 1365543-42-5
4-[{4-(5-formylbenzimidazol-2-yl)benzoyl}amino]-2,2,6,6-tetramethylpiperidin-1-oxyl

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

2: 5%-palladium/activated carbon; hydrogen / methanol / 40 h / 20 °C

3: sodium metabisulfite / ethanol; water / 6 h / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 19 h / -78 - 20 °C

With lithium aluminium tetrahydride; sodium metabisulfite; 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.042