{2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester
• CAS No.: 875783-58-7
• Molecular Formula: C₂₁H₃₄N₄O₇S
• Molecular Weight: 486.59
• Mol file: 875783-58-7.mol

Synonyms:{2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Chemical Property of {2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

There total 1 articles about {2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,3-bis(tert-butoxycarbonyl amino)propanoic acid (104010-92-6) + 4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → {2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester (875783-58-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1039/b501780g

Reference yield: 100.0%

{2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester (875783-58-7) → 2,3-diamino-N-[2-(4-sulfamoyl-phenyl)-ethyl]-propionamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1039/b501780g

Reference yield:

{2-tert-butoxycarbonylamino-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester (875783-58-7) → [({2-amino-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-methyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester (875783-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / HCl / dioxane / 3 h / 20 °C

2: 39 percent / BOP reagent; Et₃N / CHCl₃; dimethylformamide / 8 h / 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;

DOI:10.1039/b501780g

upstream raw materials:

2,3-bis(tert-butoxycarbonyl amino)propanoic acid

4-(2-aminoethyl)benzenesulfonamide

Downstream raw materials:

[({2-amino-1-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-methyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

({3-{2-[2-(bis-ethoxycarbonylmethyl-amino)-acetylamino]-2-[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-ethylcarbamoyl}-5-[(bis-ethoxycarbonylmethyl-amino)-methyl]-benzyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester