3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

Base Information

Chemical Name:3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one
CAS No.:1619929-48-4
Molecular Formula:C₂₂H₁₉NOS
Molecular Weight:345.465
Hs Code.:

Synonyms:3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

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Chemical Property of 3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

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Technology Process of 3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

There total 1 articles about 3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 54289-75-7
1-bromo-2-(2-thenoyl)acetylene

: 27866-39-3
1-benzyl-4,5,6,7-tetrahydro-1H-indole

: 1619929-48-4
3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

Guidance literature:: With potassium carbonate; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2014.05.099

Reference yield: 90.0%

: 1619929-48-4
3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

: 1619929-36-0
1-benzyl-2-(3-(thiophen-2-yl)isoxazol-5-yl)-4,5,6,7-tetrahydro-1H-indole

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 45 - 50 ℃; for 4h; regioselective reaction;
DOI:10.1016/j.tet.2014.05.099

Reference yield: 19.0%

: 1619929-48-4
3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one

: 13433-00-6
diethyl aminomalonate hydrochloride

: diethyl 3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-5-(thiophen-2-yl)-2H-pyrrole-2,2-dicarboxylate

: ethyl 3-amino-4-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-2-oxo-6-(thiophen-2-yl)-2H-pyran-5-carboxylate

Guidance literature:: diethyl aminomalonate hydrochloride; With caesium carbonate; In acetonitrile; at 20 - 25 ℃; for 0.5h;

3-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-1-(thiophen-2-yl)prop-2-yn-1-one; In acetonitrile; for 6h; Reflux;
DOI:10.1055/a-1681-4164