tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate
CAS No.:104436-89-7
Molecular Formula:C₂₅H₂₃F₇N₂O₄
Molecular Weight:548.457
Hs Code.:

Synonyms:tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

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Chemical Property of tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

Chemical Property:

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Technology Process of tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

There total 6 articles about tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4769-96-4
6-nitroindole

: 104436-89-7
tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃ / acetone / 48 h / Heating

2: 100 percent / acetic acid-EtOAc, H₂ / 10percent Pd/C / 24 h / 2585.7 Torr

3: Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 30 min

With hydrogen; potassium carbonate; acetic acid; ethyl acetate; triethylamine; palladium on activated charcoal; In dichloromethane; acetone;
DOI:10.1021/jm00168a036

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 104436-89-7
tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / conc. H₂SO₄ / CH₂Cl₂ / 16 h

2: 95 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 1 h / Heating; Irradiation

3: 98 percent / K₂CO₃ / acetone / 48 h / Heating

4: 100 percent / acetic acid-EtOAc, H₂ / 10percent Pd/C / 24 h / 2585.7 Torr

5: Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 30 min

With N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; hydrogen; potassium carbonate; acetic acid; ethyl acetate; triethylamine; palladium on activated charcoal; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jm00168a036

Reference yield:

: 104436-90-0
tert-butyl 3-methoxy-4-methylbenzoate

: 104436-89-7
tert-butyl 4-<<6-(heptafluorobutanamido)indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 1 h / Heating; Irradiation

2: 98 percent / K₂CO₃ / acetone / 48 h / Heating

3: 100 percent / acetic acid-EtOAc, H₂ / 10percent Pd/C / 24 h / 2585.7 Torr

4: Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) RT, 30 min

With N-Bromosuccinimide; Perbenzoic acid; hydrogen; potassium carbonate; acetic acid; ethyl acetate; triethylamine; palladium on activated charcoal; In tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jm00168a036