(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

Base Information

Chemical Name:(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride
CAS No.:1335122-80-9
Molecular Formula:C₁₂H₁₈N₄O₅*ClH
Molecular Weight:334.76
Hs Code.:

Synonyms:(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

Chemical Property:

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Technology Process of (S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

There total 6 articles about (S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1335122-95-6
C₂₂H₃₄N₄O₉

: 1335122-80-9
(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-57-9
tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-80-9
(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-58-0
tert-butyl(1S,2S)-3-azido-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-80-9
(S)-3-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-2-hydroxypropanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.008