Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)

Base Information

Chemical Name:Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)
CAS No.:790662-00-9
Molecular Formula:C₁₅H₁₆O₂
Molecular Weight:228.291
Hs Code.:

Synonyms:Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)

Suppliers and Price of Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)

Chemical Property:

PSA：26.30000
LogP:3.05350

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI)

There total 6 articles about Cyclopenta[b]pyran-7(2H)-one, 3,4,5,6-tetrahydro-5-methyl-4-phenyl-, (4R,5R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 790661-98-2
(E)-6-(1-ethoxybuta-1,3-dienyl)-4-phenyl-3,4-dihydro-2H-pyran

: 1-(4-phenyl-5,6-dihydro-4H-pyran-2-yl)-but-2-en-1-one

: 790662-00-9
5-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-cyclopenta[b]pyran-7-one

: 790662-00-9
5-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-cyclopenta[b]pyran-7-one

Guidance literature:: With Amberlyst 15; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo0489263

Reference yield: 45.0%

: 790661-98-2
(E)-6-(1-ethoxybuta-1,3-dienyl)-4-phenyl-3,4-dihydro-2H-pyran

: 1-(4-phenyl-5,6-dihydro-4H-pyran-2-yl)-but-2-en-1-one

: 790662-00-9
5-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-cyclopenta[b]pyran-7-one

: 790662-00-9
5-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-cyclopenta[b]pyran-7-one

Guidance literature:: With Amberlyst 15; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo0489263

Reference yield:

: 61198-49-0,61949-75-5,71302-21-1,25547-53-9
4-phenyltetrahydropyran-2-one

: 790662-00-9
5-methyl-4-phenyl-3,4,5,6-tetrahydro-2H-cyclopenta[b]pyran-7-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS; HMPA / tetrahydrofuran / 1.5 h / -78 °C

1.2: tetrahydrofuran / -78 - 0 °C

2.1: 58 percent / (Ph₃P)2PdCl₂; aq. K₂CO₃ / tetrahydrofuran / 2 h / 20 °C

3.1: Amberlyst 15 / CH₂Cl₂ / 15 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; Amberlyst 15; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0489263