(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Base Information

Chemical Name:(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate
CAS No.:1325235-97-9
Molecular Formula:C₃₇H₅₆N₂O₅
Molecular Weight:608.862
Hs Code.:

Synonyms:(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Suppliers and Price of (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

There total 20 articles about (4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1325235-75-3
(S,E)-N-(3-(7-hydroxy-4-methyldeca-3,9-dien-1-yl)-5-methoxyphenyl)non-8-enamide

: (S)-2-(cyclohexanecarboxamido)propanoic acid

: 1325235-97-9
(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ml200108y

Reference yield:

: 2702-58-1
methyl 3,5-dinitrobenzoate

: 1325235-97-9
(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium / 0 °C / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / -78 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; water / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: acetic acid / 1,2-dimethoxyethane / 24 h / 50 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / toluene / -78 - 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 10 h / 20 °C

7.1: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

7.2: 1 h / 20 °C / Inert atmosphere

8.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

9.1: acetonitrile / 12 h / Inert atmosphere

10.1: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Molecular sieve

10.2: 0 - 20 °C / Inert atmosphere

10.3: 0.5 h / 20 °C / Inert atmosphere

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

12.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iodine; lithium; sodium hydride; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 10.1: Wittig olefination / 10.2: Wittig olefination / 10.3: Wittig olefination / 12.1: Mitsunobu coupling;
DOI:10.1021/ml200108y

Reference yield:

: 1325235-67-3
C₁₀H₁₃NO₄

: 1325235-97-9
(4R,7E)-10-(3-methoxy-5-(non-8-enamido)phenyl)-7-methyldeca-1,7-dien-4-yl (2S)-2-(cyclohexanecarboxamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 10 h / 20 °C

2.1: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: acetonitrile / 12 h / Inert atmosphere

5.1: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Molecular sieve

5.2: 0 - 20 °C / Inert atmosphere

5.3: 0.5 h / 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 20 °C / Inert atmosphere

With 1H-imidazole; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; 5.1: Wittig olefination / 5.2: Wittig olefination / 5.3: Wittig olefination / 7.1: Mitsunobu coupling;
DOI:10.1021/ml200108y